But something is happening as Cakewalk starts that causes the system to crash, if I have my behringer interface plugged in. I also have no problem having both interfaces active when I'm not using Cakewalk. I get the message box asking if I want to add the device to the session, select 'yes' and it's completely fine and they both work together.
I can start Cakewalk with the Line6 just fine, and the most perculiar thing is: if I plug in the Behringer interface after Cakewalk has started there's no problem. However, if I try to start Cakewalk with the Behringer interface plugged in, a few seconds after the Cakewalk spalsh screen appears, the system crashes and I get the Blue Screen of Death. In Cakewalk Preferences I have the Line6 set as the audio device and the Behringer as the MIDI device, and this works fine. They are both USB ASIO interfaces and I'm using them in parallel, not connected, so they are neither synced or clocked together. I have a Line6 TonePort UX8 that I use as an audio interface and a Behringer U-Phoria UMC404HD that I only use for MIDI. I ran into a kinda similar problem a few weeks ago, but the issue was resolved.